|
KMID : 0350519930460020499
|
|
Journal of Catholic Medical College
1993 Volume.46 No. 2 p.499 ~ p.508
|
|
|
The Correlation between an Intra-erythrocytic Low Molecular weight Lead-binding Protein and Lead Esposure Parameters in Lead-exposed Workers
|
|
|
|
|
Abstract
|
|
|
It has been suggested that an intra-erythrocytic low molecular weight lead-binding protein may have a protective role in clinical, and biochemical lead toxicity. The lead produces toxicity by inhibition of &-aninolevulinic acid dehydratase
activity(ALAD).
The relationships between low molecular weight lead-binding protein in ervthrocyte and some lead exposure parameters were evaluated by measuring the blood lead level(Pb-B), zinc protoporphyrin(ZPP), ALAD with and without dithiothreitol(A-ALAD and
I-ALAD, respectively) in whole blood in 42 lead-exposed workers and 20 control subjects.
@ES The results were as follows :
@EN I-ALAD were 1023.30±200.06 μmolPBG/Lrbc/h and 329.44±98.92μmolIPBG/Lrbc/h in control and exposed group, respectively. A-ALAD in control group was 1441.86±214.92μmoIPBG/Lrbc/h and was 1337.33±233.76μmolIPBG/Lrbc/h in exposed group
The low molecular weight lead-binding protein was not detected in control group, but in exposed group, that was 27.22±13.99 mg/Lrbc. The highly exposed group(Pb-B >60.1μg/100 ml ; n=22) were divided into two subgroups : I-ALAD activity greater
than
and less than mean value. There was a statistically significant differenct in the low molecular weight lead-binding protein between these two subgroups.
The correlation coefficient between the Pb-B and the A-ALAD/I-ALAD ratio was slightly greater(r=0.68) than the correlation coefficient between the log I-ALAD and the Pb-B(r=-0.62) among 42 lead exposed workers. No statistically significant
differences
were found between the low molecular weight lead-binding protein and each of three paremeters, Pb-B, A-ALAD, and I-ALAD.
In conclusion, the level of the low molecular weight lead-binding protein in erythrocytes in highly lead-exposed workers clearly showed the reciprocal correlation to the lead toxicity parameter (ALAD). This means the low molecular weight
lead-binding
protein may suppress the expression of the lead toxicity. Therfore, screening at the beginning of lead work and periodic measurement of the low molecular weight lead-binding protein are believed to be a valuable method to predict the task
fitness
of
the lead workerμ
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|